Both on weekends of calorie abandonment.
New research confirms that only two days of eating a diet rich in fat can compromise the immune cells of critical intestine and weaken the intestinal barrier, which suggests that the impact of our daily dietary options is more immediate than it was believed before.
This month, published in Immunity Magazine, research followed mice fed on a regular diet, a diet rich in fat and specialized diets enriched with saturated and unsaturated fats.
The fat-rich diet led to the rapid deletion of specialized immune cells called ILC3S, which produce a protective substance called the interleukin-22 (IL-22). This suppression is disastrous for the digestive system.
Within the intestine, IL-22 is usually described by the intestinal barrier, generating protection elements that prevent bacteria, toxins, non-digested food particles, and inflammatory pathogens from violating the bloodstream.
When a diet rich in fat limits IL-22 production, this intestinal barrier becomes more permeable, a well-known condition, ineligible, as a “fleeting intestine”.
Although it is not a formal diagnosis, it is known that the leak gut causes swelling, constipation, indigestion, acid reflux and potentially intestinal pain.
Worse, when toxins are filtered beyond the intestine, they trigger widespread inflammation, causing problems such as skin problems, brain fog, anxiety, depression, cardiovascular stress and even fertility challenges.
“The most saturated fats eat, more inflammation that is built,” said the author of the Walter Cyril Seillet studio and the Walter and Eliza Hall Medical Research Institute in Australia. “This accumulation of inflammation is initially silent, it is hidden in our bodies until years later, where it can be presented as chronic inflammation.”
Seillet and his team discovered that different fats have different effects on intestinal health.
They found that unsaturated fatty acids, found in olive oil and avocados, helped to support normal IL-22 production and the function of intestinal barrier.
In contrast, saturated fatty acids, present in palm oil, butter and fatty animal meat, provide a punch to two, severely difficult to function as immune cells and increasing intestinal inflammation.
After only two days on high fat diets, researchers noticed that certain subtypes of Immune cells ILC3 already had a small production of IL-22. One week in the diet rich in fat, all the subtypes ILC3 were committed.
In addition, in a week of the fat -rich diet, the intestinal microbiome had changed rapidly, showing a decrease in beneficial bacteria that produce short chain fatty acids and a proliferation of harmful bacteria.
Using specialized equipment, the research team distinguished that one week in a fat -rich diet correlated with the “feakier” mice of the intestines, a permeability that allowed to pass more potentially dangerous substances.
There is a little silver (intestinal) coating that can be found in the latter batch of research: the consequences that compromise the intestines of a fat -rich diet are not permanent.
The research team found that after resuming a regular diet, intestinal function improved two days after normal after seven days. This rapid correction suggests that dietary interventions could quickly restore intestinal health.
In addition, researchers found that saturated and unsaturated fatty acids are processed in completely different ways.
Saturated fats are processed through a path called oxidation of fatty acids, which deteriorates immune function, while unsaturated fats such as oleic acid form protective lipid droplets in cells, helping to maintain appropriate immune responses.
To demonstrate how the processing of these fats influences intestinal inflammation, the research team induced colitis in mice. Saturated fat -fed mice showed greater damage to tissues than those who ate unsaturated fats or would attach to a regular diet.
The results were similar when the team exposed immune cells isolated to different fatty acids. Essentially, unsaturated fats support the immune function, while saturated fats suppress IL-22 production.
Researchers believe that these rapid and deep changes in intestinal health could explain why people experience digestive discomfort when they come from their usual diets during the holidays or on vacation.
These results, on the other hand, explain why diets rich in olive oil and unsaturated fats, such as the Mediterranean diet praised, are associated with lower levels of inflammation and improving intestinal health.
How important is intestinal health? Research reports that Parkinson’s disease can begin in the intestine.
A 2022 study of the University of Clarkson in New York even found a possible link between a person’s intestinal health and intestinal personality.
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